THEME: "Frontiers in Drug Discovery, Development and Lead Optimization"
Malatya Turgut Ozal University, Turkey
Title: Spectroscopic and Photonic Properties of Dexamethasone used in the Treatment of COVID-19 Patients
Bayram Gündüz received his bachelor’s degree in Physics from
Firat University, Elazig, Turkey, 2001–2005, master degree from Solid State
Physics, Firat University, 2005–2007, PhD degree from Solid State Physics,
Firat University, 2007–2011. He was research assistant in Solid State Physics,
Mus Alparslan University, Turkey, 2009–2011 and was Assist. Prof. Dr. in Department
of Science Education, Mus Alparslan University, 2011–2017. He was an Assoc.
Prof. Dr. in the same department and university, 2017-2019. He is currently an
Assoc. Prof. Dr. in Malatya Turgut Özal University, since November 2019. His
main achievements include organic semiconductors and optoelectronic materials:
(i) electrical, optical, photonic and optoelectronic properties; (ii)
fabrication of electronic and optoelectronic devices and and investigation
their photophysical properties and applications such as Schottky diode, P–N
heterojunction diode, metal–insulator–semiconductor junctions, solar cells,
thin-film transistor, photodiode. (B) He has many articles (more than 70) published in
SCI, SCI-Exp journals, which have high impact factors and has about 820
citations to his studies.
Dexamethasone is a synthetic adrenal corticosteroid
with potent anti-inflammatory properties. Dexamethasone (MK-125) is a position
9 fluorinated corticosteroid used to treat endocrine, rheumatic, collagen,
dermatological, allergic, ophthalmic, gastrointestinal, respiratory,
hematological, neoplastic, edematous, and other conditions. On June 16, 2020, a
press release for the Randomized Evaluation of COVID-19 Treatment (RECOVERY)
trial recommended the use of dexamethasone in COVID-19 patients with severe
respiratory symptoms. Dexamethasone reduced deaths by approximately one-third
in ventilated patients and one-fifth in patients requiring oxygen [1]. Therefore,
Dexamethasone is used in the Treatment of
COVID-19 Patients in some countries. In this study, we investigated the
spectroscopic properties and photonic properties of Dexamethasone. We have
extensively studied the absorption spectra at different concentrations and
their response to light. Fig. 1 shows the absorbance spectra of the Dexamethasone
for various concentrations. On the other hand, we continue to work intensively
on some herbal suggestions that can be considered equivalent to Dexamethasone.