Simone Carradori

“G. d’Annunzio” University of Chieti-Pescara, Italy

Title: Design and synthesis of carvacrol- and thymol-based derivatives as dual inhibitors of H. pylori strains and AGS cell proliferation

---

Biography

Simone Carradori completed his PhD in “Pharmaceutical Sciences” at Sapienza University of Rome (Italy). Dr. Simone Carradori has collaborated and still collaborates with several departments abroad. Now he is assistant professor at the Department of Pharmacy of “G. d’Annunzio” University of Chieti-Pescara (Italy). The scientific activity is mainly focused on the characterization and synthesis of heterocyclic derivatives with potential biological activity, and is documented from about 186 papers in international peer-reviewed journals, one patent and participations in numerous conferences. He is in the Editorial Board of several peer-reviewed journals.

Abstract

This study describes the synthesis, purification, structural assessment, microbiological screening against nine strains of H. pylori (one reference strain and eight clinical isolates) and antiproliferative activity against AGS cells of a large array of carvacrol-and thymol-based compounds. Structural analyses consisted of elemental analysis, 1H/13C/19F NMR spectra and crystallographic studies. Starting from these premises and keeping in mind that the development of drugs from these plant secondary metabolites is a topic of the most recent ongoing research and engages large-scale pharmacological screenings of extracts and active compounds, we aimed at designing a large library of carvacrol- and thymol-based derivatives (ethers and esters) possessing tuneable functional groups for their chemical modulation to desired properties and assuring the broadest chemical diversity. Structure-activity relationships can be esasily extrapolated. Indeed, natural product derivatives could shed light on new therapeutic agents against human diseases due to the modulation of the physical-chemical, toxicological and drug-like characteristics of their natural parent compound. This is very important when also addressing pathologies such as gastric cancer where a pluralism of causative factors must be faced by a feasible research strategy which can evolve a multi-targeted perspective (one molecule acting on separate targets of the disease). Moreover, this approach can overcome issue related to combination therapy and the possibility of drug-drug interactions. These newly synthesized compounds can be considered as new lead compounds able to reduce H. pylori growth and to counteract the proliferation of AGS cells.