Prof. Vladislav Tomiši?

University of Zagreb, Croatia

Title: Supramolecular receptors for cations and anions: thermodynamic aspects of coordination reactions

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Biography

Vladislav Tomiši? graduated and received the Ph.D. degree in Natural Sciences, Chemistry, from the Faculty of Science, University of Zagreb, Croatia. He was postdoctoral researcher and visiting scientist in several institutions in France and Germany. After serving as Head of the Division of Physical Chemistry and Head of the Department of Chemistry, Faculty of Science, Zagreb, currently he is a full professor of physical chemistry at the same Department. His research interests are mainly related to the thermodynamic and kinetic aspects of solution chemistry and supramolecular systems, particularly the thermodynamics of anion and cation complexation reactions. He has authored 67 publications (>1250 citations, h-index = 20) and has been leader of numerous scientific projects, including those in collaboration with pharmaceutical industry. V. Tomiši? received a number of recognitions and awards for his scientific work. He has been a member of the Editorial Boards of several international chemical journals, and has been involved in various IUPAC activities as Croatian national representative and Associate Member of the Physical and Biophysical Chemistry Division. Currently he is the president of the Croatian Chemical Society  

Abstract

In the first part of the lecture, coordination chemistry of calixarene derivatives will be discussed from thermodynamic and structural points of view. Calixarenes are macrocyclic oligomers which consist of four or more phenolic residues linked by methylene group in the ortho position. Many calixarene derivatives are known to be very efficient, and, in some cases, selective binders of ions and neutral molecules. A comprehensive investigation of several complexation reactions of these compounds will be described, and the obtained thermodynamic data (complex stability constants and derived reaction Gibbs energies, reaction enthalpies and entropies) will be correlated with the structural findings. The intra- and intermolecular hydrogen-bonding and solvent effects (especially specific solvent-solute interactions) on the equilibria of binding reactions will be particularly addressed.

The second part of the lecture will be devoted to amine-, amide-, urea-, thiourea-, and cyclopeptide-based anion receptors. A detailed thermodynamic characterization of complexation reactions of these compounds with a series of inorganic and organic anions in several solvents will be presented. The solvent effect will be emphasized, and the importance of protonation, dimerization, and homoconjugation processes in determining the extent of anion-binding reactions will be discussed.