Shengqing Yu

Shanghai Veterinary Research Institute, China

Title: Brucella infection regulates thioredoxin-interacting protein expression to facilitate intracellular survival by reducing the production of nitric oxide and reactive oxygen species

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Biography

Shengqing Yu has her expertise in pathogenesis research of Brucella abortus. Her research group has identified 34 novel genes essential for Brucella abortus to establish infection by signature-tagged mutagenesis, constructed of pTM series plasmids for gene expression in Brucella species. found that Brucella rough mutant induce macrophage death via activating IRE1? pathway of endoplasmic reticulum stress by enhanced T4SS secretion. Furthermore, used a comparative proteomics analysis revealed OmpW family protein (BAB1_1579) and uncharacterized protein BAB1_1185, two differential secretory proteins, were associated with Brucella cytotoxicity.

Abstract

Pathogenesis Research