Ofer Binah

Technician, Israel-Institute of Technology, Israel

Title: Depressed Beta-adrenergic inotropic responsiveness and intracellular calcium handling abnormalities in Duchenne Muscular Dystrophy patients’ induced Pluripotent Stem Cell-derived cardiomyocytes

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Biography

Prof. Ofer Binah is Chair of the Department of Physiology, Biophysics and Systems Biology, at the Ruth & Bruce Rappaport Faculty of Medicine, Technion, Israel. Ofer Binah is a cardiac physiologist working for the past 33 years on research topics related to cellular electrophysiology, mechanics, signalling pathways and arrhythmias. In addition, Ofer Binah investigated the cellular mechanisms whereby cytotoxic T lymphocytes destroy cardiomyocytes in the course of heart transplant rejection and inflammatory heart diseases. Since 2001 Binah is investigating the functional properties of human embryonic stem cell-derived cardiomyocytes, and have published several papers in this area. Over 10 years ago Binah has begun investigating iPSC-derived cardiomyocytes generated from both dermal fibroblasts and keratinocytes, from healthy volunteers and from patients with inherited cardiac pathologies, including inherited arrhythmias and cardiomyopathies such as Duchenne Muscular Dystrophy.

Abstract

Investigating inherited arrhythmias and cardiomyopathies using the patients' induced Pluripotent Stem Cell-derived cardiomyocytes.