Benaziz Ouarda

Blida 1 University, Algeria

Title: Formulation and evaluation of fast disintegrating tablets using polyfunctional matrix

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Biography

Introduction: Coprocessed excipients are widely used in the manufacture of fast disintegrating tablets by simple physical mixing followed by direct compression. They have good rheological properties and make it possible to correct the poor compressibility properties of these active principles. Due to swallowing difficulties, rapidly disintegrating tablets are used for children and the elderly. Method: The purpose of this work is to formulate an orodispersible tablet by developing a fast disintegrating matrix that represents a charge excipient for these tablets. The excipients used are: mannitol as a diluent, corn starch as a binder, crospovidone as a disintegrating, colloidal silica as a flow and permeabilizing agent and sodium lauryl sulphate as a lubricant. For a first approach, preliminary tests made it possible to define the proportion of the binder in the formula. Subsequently the retained formula was improved by incorporating a disintegrating and a flow agent. The matrix obtained meets the objectives initially set; disintegration time less than 3 minutes and sufficient hardness of the tablets. This matrix has been applied to several active substances. Results: pharmacotechnical controls are carried out both on the granule and on the tablet (placebo), residual moisture content of the granules is 3, 2%, flow time=7,76 ±0,35 seconds, friability=0,53%±0,02, disintegration time=30±2 seconds, wetting time=28±0,81 seconds. Direct compression was used to prepare tablets contains furosémide. The tablets obtained were evaluated: content uniformity=102, 51 %, disintegration time=25 seconds, dissolution test=not less than 99% in 15 minutes.

The results are in accordance with specifications of pharmacopeia.

Abstract

Benaziz Ouarda is  DPharm, Pharmacist specializing in Galenic pharmacy having experience of 15 years in the pharmaceutical industry, particularly in pharmaceutical research and development

Professional skills: pharmaceutical formulation, pharmaceutical expertise, nanotechnology (insulin-based nanoparticle formulation for oral administration), application of biopolymers in the formulation of modified-release pharmaceuticals forms, Biopharmacy, process development and validation, development and validation of coating processes, formulation of herbal medicines, pediatrics formulations, securing care in hospital