Sandrija Capkauskiene

Kauno kolegija Higher Education Institution, Lithuania

Modulation of facial skin biomarkers through a targeted antioxidant nutritional intervention: a 12-week randomized placebo-controlled study

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Biography

Dr. Sandrija Capkauskiene is an Associate Professor at Kauno kolegija: Higher Education Institution, Department of Cosmetology, and holds a PhD in Biomedical Sciences. Her academic work focuses on nutricosmetics and lifestyle factors influencing skin health. She is actively involved in research and academic activities, contributing to the advancement of biomedical science through teaching and scientific publications.  

Abstract

Background: Contemporary longevity science increasingly recognizes skin as a sensitive peripheral biomarker of systemic ageing, reflecting oxidative stress, chronic low-grade inflammation (inflammaging), and impaired barrier function. Nutritional strategies targeting these pathways may support skin resilience and delay visible manifestations of biological ageing. Glofix is a multi-component antioxidant formulation combining DracoBelle™ Nu, astaxanthin, vitamins C and E, biotin, zinc, selenium, copper, amino acids, and botanical compounds, designed to support redox balance, collagen metabolism, epidermal barrier integrity, and inflammatory homeostasis.

Objective: To evaluate the effects of a targeted antioxidant nutritional intervention on objective facial skin biomarkers associated with ageing, barrier function, pigmentation, and inflammation.

Methods: In this 12-week randomized, placebo-controlled, single-blind study, 70 healthy women aged 35–50 years were allocated to receive either Glofix or placebo. Primary endpoints included facial skin hydration, firmness/elasticity, viscoelasticity, transepidermal water loss (TEWL), melanin index, and erythema. Objective assessments were conducted using DermaLab Combo and VisioFace RD systems. Visual imaging and structured self-assessment questionnaires complemented instrumental measurements.

Results: After 12 weeks, the Glofix group demonstrated significant improvements compared to placebo: viscoelasticity increased by 6.6%, firmness/elasticity by 5.8%, hydration by 7.5%, while TEWL decreased by 16.9%, melanin index by 8.0%, and erythema by 14.6%. Imaging analyses confirmed reduced facial redness, improved pigmentation uniformity, and enhanced skin texture. Participants also reported improved skin smoothness, elasticity, and reduced sensitivity.

Conclusions: This targeted antioxidant nutritional intervention significantly improved key facial skin biomarkers linked to oxidative stress, epidermal barrier function, and inflammaging. These findings suggest that multi-component nutritional strategies may represent a relevant adjunct approach within longevity-oriented interventions aimed at preserving skin integrity and biological resilience during midlife ageing.