Sandrija Capkauskiene

Kauno kolegija Higher Education Institution, Lithuania

Modulation of facial skin biomarkers through a targeted antioxidant nutritional intervention: a 12-week randomized placebo-controlled study

---

Biography

Abstract

Background: Contemporary longevity science increasingly recognizes skin as a sensitive peripheral biomarker of systemic ageing, reflecting oxidative stress, chronic low-grade inflammation (inflammaging), and impaired barrier function. Nutritional strategies targeting these pathways may support skin resilience and delay visible manifestations of biological ageing. Glofix is a multi-component antioxidant formulation combining DracoBelle™ Nu, astaxanthin, vitamins C and E, biotin, zinc, selenium, copper, amino acids, and botanical compounds, designed to support redox balance, collagen metabolism, epidermal barrier integrity, and inflammatory homeostasis.

Objective: To evaluate the effects of a targeted antioxidant nutritional intervention on objective facial skin biomarkers associated with ageing, barrier function, pigmentation, and inflammation.

Methods: In this 12-week randomized, placebo-controlled, single-blind study, 70 healthy women aged 35–50 years were allocated to receive either Glofix or placebo. Primary endpoints included facial skin hydration, firmness/elasticity, viscoelasticity, transepidermal water loss (TEWL), melanin index, and erythema. Objective assessments were conducted using DermaLab Combo and VisioFace RD systems. Visual imaging and structured self-assessment questionnaires complemented instrumental measurements.

Results: After 12 weeks, the Glofix group demonstrated significant improvements compared to placebo: viscoelasticity increased by 6.6%, firmness/elasticity by 5.8%, hydration by 7.5%, while TEWL decreased by 16.9%, melanin index by 8.0%, and erythema by 14.6%. Imaging analyses confirmed reduced facial redness, improved pigmentation uniformity, and enhanced skin texture. Participants also reported improved skin smoothness, elasticity, and reduced sensitivity.

Conclusions: This targeted antioxidant nutritional intervention significantly improved key facial skin biomarkers linked to oxidative stress, epidermal barrier function, and inflammaging. These findings suggest that multi-component nutritional strategies may represent a relevant adjunct approach within longevity-oriented interventions aimed at preserving skin integrity and biological resilience during midlife ageing.