Aurelija Radzeviciene

Kauno kolegija Higher Education Institution, Lithuania

Title: Nutritional supplement effect on facial skin and oxidative stress indicators: a randomized, placebo-controlled study

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Biography

Aurelija Radzeviciene, Ph.D., is a biomedical scientist and assoc. prof. at the Lithuanian University of Health Sciences and Kauno kolegija. She specializes in pharmacology, physiology, and pharmacokinetic modeling, with a strong focus on individualized immunosuppressive therapy and translational research. Her doctoral work applied Bayesian models to assess immunosuppressant pharmacokinetics in kidney transplant recipients. Over the past decade, she has contributed to projects on pulmonary hypertension, COVID-19-related cardiovascular dysfunction, and regenerative medicine. She is internationally trained in PBPK modeling, she collaborates through COST Action TEATIME and reviews for leading journals. Recent works include several articles on antimicrobial resistance mechanisms and strategies, and innovation in skin health solutions, aligning with global trends in advanced dermatological formulations. A member of British pharmacology society, she also serves as an ethics expert and evaluator for the Lithuanian Research Council, advancing pharmacotherapy and biomedical ethics in Lithuania and beyond.

Abstract

Nutrition and dietary supplements have been used to promote a youthful appearance for millennia. Despite high public demand for these products, evidence supporting their efficacy is limited and often inconsistent. We have performed the study evaluating of nutritional food supplement impact on women face skin condition as moisture, elasticity and oxidative stress.

Food supplement consists of compounds (coenzyme Q10, vitamins A, C, D and E, herbal extracts etc.) highly studied for the skin health, protection of the environmental factors and aging. 

Methods: The study was randomized placebo-controlled, included 70 women (35-45 years) without botulinum toxin or tissue filler injections at least 6 months before the study. Skin parameter measurements were conducted using the non-invasive diagnostic device DermaLab Combo (Cortex Technology). Oxidative stress was evaluated by analysing MDA, hs-CRP and IL-6 levels in the blood.

Results: Improvement of the women face skin condition was noticed after 5 days and significant improvement after 15 days of food supplement usage. Facial skin elasticity, resilience/tension increased by 2.67 percent, moisture by 20.25 percent, erythema decreased by 12.96 percent in Food supplement group after 15 days of usage. 

Testing of oxidative stress showed that women using Food supplement had 2.3 percent higher MDA level than the Placebo group. Although all C-reactive protein values were within the normal range, the initial C-reactive protein results revealed a 30.3 percent lower C-reactive protein level in the women taking Food supplement. Both the Placebo and Food supplement groups had similar levels of IL-6.

Conclusions: The usage of Food supplement positively impacts viscoelasticity, resilience/tension, and moisture of the facial skin within the first positive changes observed in 5 weeks and a significant improvement noticeable after 15 weeks; effectively reduces micro inflammatory processes, especially erythema, speeds up the recovery of the hs-CRB index, reduces MDA level and has an antioxidant effect.