Adesola A. Adeleke

Olabisi Onabanjo University, Nigeria

Title: The structural activity relationship and anion-controlled quinolinyl Ag(I) complexes: Molecular docking, Antimicrobial and Antioxidant activities as well as their interaction with macromolecules

---

Biography

Abstract

In this communication, we feature the synthesis and in-depth characterization of a series of

silver(I) complexes obtained from the complexation of quinolin-4-yl Schiff base ligands ((E)-

2-((quinolin-4-ylmethylene)amino)phenol La, 2-(quinolin-4-yl)benzo[d]thiazole Lb, (E)-N-(2-

fluorophenyl)-1-(quinolin-4-yl) methanimine Lc, (E)-N-(4-chlorophenyl)-1-(quinolin-4-yl)

methanimine Ld, (E)-1-(quinolin-4-yl)-N-(p-tolyl)methanimine Le, (E)-1-(quinolin-4-yl)-N-

(thiophen-2-ylmethyl)methanimineLf) and three different silver(I) anions (nitrate, perchlorate

and triflate). Structurally, the complexes adopted different coordination geometries, which

included distorted linear or distorted tetrahedral geometry. The complexes were evaluated in

vitro for their potential antibacterial and antioxidant activities. In addition, their interactions

with calf thymus-DNA (CTDNA) and bovine serum albumin (BSA) were evaluated. All the

complexes had a wide spectrum of effective antibacterial activity against gram-positive and

gram-negative bacterial and good antioxidant properties. The interactions of the complexes

with CT-DNA and BSA were observed to occur either through intercalation or through a minor

groove binder, while the interaction of the complexes with BSA reveals that some of the

complexes can strongly quench the fluorescence of BSA through the static mechanism. The

molecular docking studies of the complexes were also done to further elucidate the modes of

interaction with CT-DNA and BSA.