Ajaykumar Rikhabchand Surana

K.K.Wagh College of Pharmacy, India

Title: An ameliorative effect of natural antioxidants on antidepressant activity in animal models

---

Biography

My self Dr. Ajaykumar Surana working as Associate professor at K.K.Wagh College of Pharmacy. I completed B. Pharm. in 2004 from North Maharashtra University, Jalgaon and M. Pharm. (Pharmacognsoy) from University of Pune in 2006 with first Class. Doctor of Philosophy (Ph.D.) in Pharmacy in September 2018 from North Maharashtra University, Jalgaon. I have 16 years of teaching experience and published around 21 research papers in National and International Journals, presented 22 research papers in various conferences and published 1 book. My area of research includes drug discovery through natural sources like isolation of Phytoconstituents using chromatographic and hyphenated chromatographic techniques and screening for antioxidant activity, anti-inflammatory, antidepressant and Cytotoxic activity. I have guided 2 post graduate students (M. Pharm.) for their dissertation work and Guided 326 B. Pharm. students for their project work.   I was completed two minor funded research project under BCUD University of Pune.

Abstract

Depression is often manifesting with various symptoms at the behavioral, psychological and physiological levels.  Oxidative stress has shown important biochemical aspects in the depression. This study aim to evaluate effect of natural antioxidant on antidepressant activity of polyherbal formulation on the performance of mice. Antioxidant Activity of polyherbal formulation were performed by Nitric oxide scavenging assay, Hydrogen peroxide scavenging activity and DPPH free radical scavenging Assay Mice were given orally polyherbal formulation without antioxidant (PF-1 and) with antioxidant (Pf-2) daily for 7 days and then subjected to forced swim test (FST) and tail suspension test (TST).  After one-week treatment, both polyherbal formulation significantly reduced immobility time in FST and TST compared with vehicle treated control group. The immobility time in TST of PF-1 and PF-2 was found to be 151.17±4.46s & 116.33 ±8.84s respectively. The immobility time in TST of PF-1 and PF-2 was found to be 137.17±5.93s, 113.50±5.40s respectively. PF-2 shows significant difference with PF-1 in antidepressant activity. These results indicate that the antidepressant when given along with antioxidant in mice it gives significant antidepressant effect as compared to formulation without antioxidant. The experimental results suggest that the intake of antioxidant may help in reducing the symptoms of depression, via supplementation of antioxidant.