S Jhaumeer Laulloo

Univeristy of Mauritius, Maurituis

Title: Structure, Biological and Catalytic acitivities of Diphenylsulfide derivatives

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Biography

S Jhaumeer Laulloo has a Personal Chair in Organic Chemistry at  University of Mauritius. She is recogized nationally and internationally for her research contributions and achievements in Organic and Surfactant Chemistry and aslo  Organometallic compounds. She is also interested in Forensic Science. She has published over 80 papers in peer reviewed journals. 

Abstract

Diphenyl disulfide scaffold is considered among one of the most momentous structural motifs in chemistry that have sparked a growing interest among researchers due to the interesting biological and catalytical properties. Multiple studies have demonstrated the effectiveness of diaryl disulfides as promising anticancer, herbicidal  and antibacterial agents. Diaryl sulfides possess flexible Sn spacer groups giving rise to mononuclear, binuclear or polynuclear complexes when coordinated to metal centers.

Diaryl disulfide derivatives with varying alkyl chain length showed interesting physicochemical properties and  antibacterial activities. The C10/C12 alkyl chains showed optimum activity as a result of an ideal hydrophobic-hydrophilic balance that enhanced interaction and penetration of the molecule  inside the  bacterial membrane. An increase in chain length caused an increase in the affinity with (Bovine Serum Albumin) BSA up to a chain length of C12, above which the binding ability decreased and the interaction were mainly via van der Waals' forces and hydrogen bonding. Increasing hydrophobicity of diphenyldisulfide salicyldiimine derivatives by introducing t-butyl group contributed to higher anti-oxidant properties.

Co-ordination of metals to these diaryl sulfides occurs either with or without the S-S cleavage. Many of these metal complexes exhibited promising antibacterial and antioxidant activities which were due to the presence of larger planar geometries and S–S linkages. These complexes  also act as potential catalyst in C-C bond formation in organic reactions such as Mizori-Heck and Suzuki -Miyaura.

The biological and distribution of these diary disulfides in plasma proteins were influenced by their lipophilicity. Their metal complexes also proved to be efficient catalysts.