ASHUTOSH MISHRA

Panacea Institute of Interdisciplinary Research & Education, India

Title: Parsimonious Use of Oral GLP-1 Receptor in Diabetes Management – An Exploratory Study

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Biography

Ashutosh Mishra is a renowned Endocrinologist and Diabetologist from Varanasi. He has done his MBBS and MD from prestigious Institute of Medical Sciences, BHU and Fellowship in Diabetes from CMC Vellore. He is the Founder Director of Panacea Hospital and Diabetes Care Organization, where he also serves as head of Endocrinology, Diabetes & Metabolism. He has also served as an endocrinologist at prestigious hospitals like SGPGI, Lucknow and FORTIS Hospital, New Delhi. He is also the National Coordinator for Cardio-Diabetes Self-Management Education (CDSME) Program and Dean of Panacea Institute of Interdisciplinary Research and Education. He is also the national secretary of CARDIABON -A Society of Cardio Diabetes and Renal Disease.

Abstract

GLP-1 receptors are gaining acceptance as a first-line drug in diabetes management. It is a non-insulin treatment for type 2 diabetes mellitus (T2DM). An adjunct to diet and exercise, its use is linked with improved glycemic control in adults living with T2DM. Presently the guidelines suggest using 7 mg or 14 mg tablets once a day. The major concern with the drug is the cost of the therapy which eventually results in nonadherence to the treatment regime. This prospective study investigates the efficacy of oral GLP-1 receptors once a week. The study was planned in a hospital setting involving patients having the intention to use the therapy. The GLP-1 receptors were used in addition to existing therapy and the results were analyzed. The enrolled patients were evaluated on follow-ups for outcomes using anthropometric and non-anthropometric biomarkers such as HbA1c, Body Max Index (BMI), and Waist Circumference (WC). The sampling method used for the study is non-probabilistic purposive sampling. The sample size for the study was taken 98 using Cochran’s Formula. Before and after analysis of the effect was done using paired t-tests using SPSS 26. The three hypotheses were tested (1) the proposed intervention reduces HbA1c by more than 1% (2) the proposed intervention reduces BMI by more than 2 units, and (3) the proposed intervention reduces WC by more than 2 units. The study gets favorable results for the first two hypotheses while the results for the third hypothesis were negative. The results of the exploratory study suggest that parsimonious use of GLP-1 receptors should be promoted for economically weaker patients. The findings of the study are useful for clinicians, researchers, and policymakers.

Keywords: GLP-1, T2DM, Parsimonious Use, Prospective Study