Adnan Haider

King Edward Medical University

Title: Efficacy of Whole-Blood Del Nido Cardioplegia Compared with Diluted Del Nido Cardioplegia in Coronary Artery Bypass Grafting: A Retrospective Monocentric Analysis of Pakistan

Biography

Adnan Haider is a Certified Clinical Cardiac Perfusionist with over 13 years of experience, specializing in extracorporeal circulation. He has independently managed more than 2,500open-heart surgeries, including 135 minimally invasive procedures. He serves as a Lecturer and Chief Cardiac Perfusionist at King Edward Medical University(KEMU), Lahore, where he has been actively engaged in teaching, training, and research since 2012. Haider holds a Ph.D. and an M.Phil. in Physiology from the University of Veterinary and Animal Sciences, Lahore. His expertise includes cardiopulmonary bypass, myocardial protection, ECMO, and temperature management. He has contributed extensively to research, with multiple publications in peer-reviewed journals, and has been recognized for his excellence in teaching and perfusion strategies. He has also served as a keynote speaker at international conferences.

Abstract

Cardioplegia is one of the most significant components used to protect the myocardium during cardiac surgery. There is a paucity of evidence regarding the utilization of whole-blood Del Nido cardioplegia (WB-DNC) on clinical outcomes in coronary artery bypass grafting (CABG). The purpose of this retrospective cross-sectional study is to compare the effectiveness of diluted (blood to crystalloid; 1:4) Del Nido cardioplegia (DNC) with WB-DNC in patients who underwent elective CABG in a tertiary care hospital in Lahore-Pakistan. Materials and Methods: This was a retrospective descriptive study conducted at the Department of Cardiovascular Surgery, King Edward Medical University, Lahore. The medical database of all consecutive patients admitted from January 2018 to March 2020 and fulfilled the inclusion criteria were reviewed. Results: Out of 471 patients admitted during the study period, 450 underwent various elective cardiac surgeries. Out of 450, 321 patients (71.33%) were operated on for CABG. Only 234/321 (72.89%) CABG patients fulfilled our inclusion criteria. 120 (51.28%) patients received WB-DNC, while 114 (48.71%) patients were administered with DNC. The former group presented with better clinical outcomes compared with the latter in terms of lesser requirements of inotropic support, low degree of haemodilution, shorter in-hospital stay, improved renal function, and cost-effectiveness. Peak values of serum troponin-t (Trop-T), creatine kinase-myocardial band (CK-MB) release, and activated clotting time (ACT) were also lower in the WB-DNC group compared with the DNC group. Conclusions: The WB-DNC conferred better myocardial protection, improved early clinical outcomes, and also proved to be economical for patients undergoing elective CABG compared with classical crystalloid cardioplegia solution.