Victor O. Fadipe

University of Zululand, South Africa

Title: Mechanochemical synthesis, PXRD, TGA, SEM characterization and antimycobacterial study of co-crystal of oleanolic acid with isoniazid.

---

Biography

Abstract

The work presented here involves investigation of co-crystals involving isoniazid and oleanolic acid. A 1:1 co-crystal involving isoniazid with oleanolic acid, Isoniazid, a foremost first-line drug recommended by the World Health Organization for the treatment of tuberculosis, which causes damage to the liver and oleanolic acid, a hepatotoxicity naturally occurring compound and posses moderately antimycobacterial activity, The cocrystal between the two compounds have been synthesized for the first time. Considering drug combination perspective, this is an interesting pharmaceutical co-crystal because of the known side effect of isoniazid therapy which might be improved upon by the presence of the oleanolic acid. The co-crystal compound was characterized using PXRD, TGA and SEM which were further evaluated for in vitro anti-TB and cytotoxicity and selectivity index, using Human Embryonic Kidney (HEK 293) and Human Hepatocellular carcinoma (HepG2) cells.