Prachi Khamkar

University of Mumbai, India

Formulation and Development of Anti-Fungal Film Forming Gel for Topical Drug Delivery

Biography

Prachi Khamkar obtained her Bachelor’s degree in Pharmaceutical Science from Shivaji University. She has two years of Research experience at University of Mumbai. She is currently working as Project mentor at CiREE Edutech, Pune for Pharmaceutical Manufacturing Operations. She has guided students with Pharmaceutical background for bridging gap between industry and colleges. She has also worked as Scientific Writer at Next Big Innovation Labs, Bangalore. She has also recived first position at Gdansk Technical University, Poland for Pharmaceutical 3D Printing Polymers. Her Area of Interest includes Topical Drug delivery and 3D Printing. Received numerous awards for Scientific and Professional bodies at National and International Platforms for 3D Printing in Healthcare sector. She has published several review articles and book chapters based on 3D Printing Technology in Pharmaceutical for International Publication.

Abstract

The primary goal of this research is to provide an alternate medication delivery method to the traditional topical and transdermal formulations. Our formulation also contributes toward less frequent application and longer skin-residence times. The formulation offers high medication penetration and aesthetic qualities since it sticks to your skin. Localised action is preferred and better for chronic treatment. Film forming gels have an advantage over conventional because they are semisolid as gel and also give sustained release properties like patches. We can also adjust the release kinetics and support sustained release of the drug in film forming gel formulation. Film forming gel increase retention of gel on skin thus allowing continuous release of drug and maintaining its diffusion to the site of action. Stable film forming gel of Clotrimazole were prepared with carbapol and sepineo as a gelling agent and HPMC EM4, kollicoat IR and kollidone VA64. The gels were evaluated for pH, viscosity, spreadability, retention time, in-vitro and ex-vivo release profile and skin irritation test. The relative simplicity in

formulation, manufacturing, and low cost are added advantages apart from wipe off resistance, sustained release for 6 to 8 hrs, flexibility, non tacky , adhesive and peel-able films. Patients will be more accepting of such formulations that claim to shorten the length of medication. Potential of good customer acceptance. Film-forming topical dosage forms have applications in a variety of medical situations, including wound care, scar masking, sunscreen filters, skin cancer prevention and therapy, and cosmetics