Saloni Sharma

JSS College of Pharmacy, India

pH Responsive Metallic Nano-theranostics with active receptor target towards CRC reduction

Biography

Abstract

Colorectal cancer is one of the leading causes of death worldwide that has shown 24% increase statistically by the WHO. It has been a tedious outlook towards this research on the outcome for the reduction of CRC. As a result, it has paved way for advancements towards nano-technology for the treatment and management of CRC. One such branch is the application of theranostics that imparts as a dual role of diagnostic and a therapeutic moiety functioning simultaneously. In this study, we will illustrate the effect of metallic theranostics using the photodynamic therapy towards the diagnosis of CRC. The formulation strategy implemented consists of an effective polymer with the combination of desired choice of surfactant that is the critical formulation parameter for effective formulation development, followed by the synthesis of metallic nano-particles infused with the anti- cancer agent coated with receptor for active cancer target. The receptor layer on the outer coating of metallic nano-particle acts as an active tumor target. This novel approach is opted due to its reduction in toxicity, controlled release, pH-maintained environment and reduction in particle size. As a result, we will prove a novel theranostic approach towards CRC treatment.