Rana M.F Sammour

Dubai Pharmacy College for Girls, Dubai, UAE

Title: Development and In Vitro Evaluation of Mucoadhesive Buccal Film of Aceclofenac

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Biography

Rana M.F Sammour has completed her MPharm and PhD in Pharmaceutical Technology.  She is working as an assistant professor in Dubai Pharmacy College in the Pharmaceutics department. She has published many researches in international conferences and journals. The interest of her researches is mainly in drug development and novel drug delivery systems. The aim of her studies is to explore the role of the novel delivery systems in improving the pharmacokinetics parameters of drugs.

Abstract

Retentive buccal mucoadhesive formulations may prove to be a viable alternative to conventional oral medications as they can be readily attached to the buccal cavity, retained for a longer period and removed at any time. This route is excellent for potent drugs especially targeted for acute conditions with a rapid clinical response due to direct access to the jugular vein and for extended therapeutic effect. Aceclofenac is an oral synthesised drug that goes under the classification of a non-steroidal inflammatory drug (NSAIDs) given for a variety of inflammatory pain conditions such as relieving pain in arthritis, gingivitis and rheumatoid arthritis.

This study aims to develop Aceclofenac mucoadhesive buccal film using different polymers and perform all the required in vitro characterization to obtain the candidate Aceclofenac buccal film.

The buccal films were prepared by solvent casting method using different polymers in different concentrations. Different characterization tests were conducted to evaluate the prepared formulas, such as film thickness, weight uniformity, folding endurance, drug content, swelling index and in vitro drug release of the prepared formulas to compare the different films prepared. Lastly, the optimized formula was chosen depending on the drug content and in vitro drug release results.

IBM SPSS® statistics and Microsoft Excel® were used for results analysis and presentation. One way ANOVA test was carried on to compare the results. The results revealed the role of the chosen factors on the drug release characteristics of the buccal film. The Aceclofenac buccal film was prepared successfully and exhibited an accepted release manner.