Manli Wang

Anhui University of Science and Technology, China

Title: Association of Coal Mine Air Pollution Exposure and Triglyceride-Glucose-Related Indices with Hypertension: Risk Assessment and Mediation Analysis

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Biography

Manli Wang, female, Teaching Assistant, received her master’s degree from Nanjing Medical University. She mainly teaches undergraduate courses including Nutrition and Food Hygiene, Preventive Medicine, and Environmental Hygiene.

Abstract

Objective: To investigate the associations of underground coal mine air pollution exposure and triglyceride-glucose (TyG)-related indices with hypertension risk, evaluate the contributions of individual pollutants, and clarify the mediating role of TyG-related indices. Methods: A cross-sectional study was conducted among 1,627 coal miners in northern Shaanxi, China. Individual cumulative exposures to coal dust (CD), carbon monoxide (CO), nitric oxide (NO), and nitrogen dioxide (NO2) were assessed. The TyG index and seven composite indices (TyG-BMI, TyG-WC, TyG-WHtR, TyG-WWI, TyG-ABSI, TyG-BRI, and TyG-CVAI) were calculated. Multivariable logistic regression was used to estimate associations with hypertension, weighted quantile sum regression was used to evaluate mixture effects and pollutant weights, and mediation models were used to estimate the proportions mediated by TyG-related indices. Results: The prevalence of hypertension was 24.4%. In the air pollution mixture, CO had the largest contribution weight (74.2%), followed by CD (11.6%) and NO (11.1%). All eight TyG-related indices were positively associated with hypertension. Compared with the lowest tertile, the highest tertiles of TyG-BMI and TyG-WHtR were associated with odds ratios of 5.77 (95% CI: 4.11-8.10) and 5.71 (95% CI: 4.07-8.01), respectively. High CO exposure was also associated with hypertension (OR = 1.32, 95% CI: 1.03-1.82). TyG-WHtR, TyG-WWI, TyG-ABSI, TyG-BRI, and TyG-CVAI significantly mediated the association between CO exposure and hypertension; TyG-CVAI showed the largest mediated proportion at 18.279% (95% CI: 4.591%-39.844%). Conclusion: High CO exposure is a major environmental risk factor for hypertension among underground coal miners. TyG-CVAI and TyG-WC may be useful metabolic indicators for hypertension risk screening in this occupational population. The association between CO exposure and hypertension may be partly mediated by impaired glucolipid metabolism and visceral adiposity.

Keywords

coal mining; carbon monoxide; triglyceride-glucose index; hypertension; mediation analysis