Shoebul Haque

King George Medical University, India

Drug Discovery, Development and Lead Optimization A Systemetic Review on Antidepressive Effect of Simvastatin in Rodents

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Biography

Dr Shoebul Haque is a first-year resident in pharmacology and therapeutics department at King George Medical University, Lucknow. He received a bachelor’s degree in Medicine from Smolensk State Medical University Smolensk, Russia in 2012. A Post graduate diploma in Maternal and Child health care from IGNOU university in 2015, Delhi and a Post graduate diploma in infectious diseases from Medvarsity in 2016.

Dr Shoebul has served as an in-charge doctor of mohalla clinic in Delhi Government and as a medical officer in Uttar-pradesh government, India. His current field placement is in pharmacology department of KGMU where he is doing research on different effect of drugs on animals in animal house of department. It works under (CPCSEA) The Committee for the Purpose of Control and Supervision of Experiments on Animals. The aim of his study to evaluate the antidepressant effect of Simvastatin which are mainly used as lipid-lowering agent.

Abstract

INTRODUCTION: Depression is one of the most common neuropsychological disorder with severe impacts on mortality and morbidity. It can be a lethal illness due to the elevated risk for suicide. Extensive use of the present antidepressant drugs usually shows no response at therapeutic levels due to neuronal adaptation. Therefore, the development of new antidepressants will be valuable in psychiatric disorders. Simvastatin, a lipid lowering drug has been shown to be effective in reducing depression in rodents. Present study aimed to investigate the potential antidepressant-like activity of simvastatin in rodents.

AIM AND OBJECTIVES: The aim of this systemic review is to assess the antidepressant effect of simvastatin in rodents.

MATERIAL AND METHODS: The study was done to find out antidepressant effect of simvastatin using the available published studies on Google scholar, PubMed. 17 studies were included for analysis.

RESULTS: Results showed that simvastatin could significantly produce an antidepressant-like effect in rodents, by different mechanisms, indicated by reduction in immobility time in both Forced Swim Test and Tail Suspension Test. Simvastatin 20mg/kg dose markedly inhibits NF-?B pathway, and probably mediated through NO-cGMP-KATP signaling system and PPAR-? receptors.

CONCLUSION: Out of 17, nine studies revealed the antidepressant effect of simvastatin. Rest of the studies having inconclusive result. On the basis of overall analysis possible antidepressant effect of simvastatin can be proposed. Further clinical evaluation is needed to be tried in human subjects, as it will be very helpful for the patients having hyperlipidemia and depression.