Yifei Fang

Southeast University, China

Title: Association of Brominated Flame Retardant Exposure with Lipid Abnormalities and Diabetes Risk: A Comparative Analysis of Traditional Models and Interpretable Machine Learning Approaches

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Biography

As a direct-track PhD candidate in Epidemiology and Biostatistics at Southeast University, I specialize in applying New Approach Methodologies (NAMs) to toxicology and public health. Building on a foundation in Preventive Medicine and early first-author publications, my interdisciplinary research integrates computational toxicology, PBPK/PBTK modeling, and organ-on-a-chip technology with AI.

My doctoral project focuses on emerging pollutants like microplastics and PFAS, developing a PBTK model for microplastics by integrating in vitro and exposomics data to elucidate chronic toxicity pathways. My ultimate goal is to create a comprehensive, animal-free toxicological assessment framework for regulatory use by synergizing AI with diverse NAM data, including IVIVE, QSAR, and organ-on-a-chip outputs.

Abstract

Brominated flame retardants; Dyslipidemia; Diabetes; Traditional statistical models; Interpretable machine learning